Fe₃O₄/HA-APTES Nanocomposite as Drug Delivery Agent

Abstract:

Fe₃O₄/Hydroxyapatite (HA)-(3-Aminopropyl)triethoxysilane (APTES) nanocomposite as a drug delivery agent was successfully synthesized. The nanocomposite was characterized using X-ray diffractometry (XRD), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, vibrating sample magnetometer (VSM), and ultraviolet-visible (UV-Vis) spectroscopy to investigate the structural, morphology, magnetic properties, and DOX drug loading and release efficiency. The XRD pattern of Fe₃O₄ /HA-APTES nanocomposite showed the formation of two phases with cubic spinel structure for Fe₃O₄ and hexagonal structure for HA. The SEM image showed that the nanocomposite morphology tended to be granular (though not perfectly granular) with a particle size distribution of 65.9 nm. The functional groups detected from the FTIR results were Fe-O at 422–602 cm^-1, indicating Fe₃O₄. Furthermore, vibrations of the phosphate group (PO₄^3-) and Si-O-C appeared at 1037 cm^-1 and 1048 cm^-1, which are characteristic of the phosphate stretch in the HA and APTES. The Fe₃O₄/HA-APTES nanocomposite exhibited superparamagnetic properties with a saturation magnetization value of 19.37 emu/g. As a drug delivery agent, the Fe₃O₄/HA-APTES nanocomposite has a DOX loading efficiency of 5.79 mg/g up to 96.51% for eight hours and a release of 16.36% over 300 min.

• Periodical: Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 68)
• Pages: 1-9
• DOI: https://doi.org/10.4028/p-3WfP8T
• Online since: June 2025
• Authors: Reny Citra Sanjaya, Joko Utomo, S.T. Ulfawanti Intan Subadra, Muhammad Safwan Abd Aziz, Nurul Hidayat, Ahmad Taufiq*
• Keywords: Drug Delivery Agent, Drug Loading and Release, Fe₃O₄/HA/APTES, Nanocomposite, Superparamagnetism

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