Interfacing Biology with Electronic Devices
Due to a number of advances in molecular biology, cell and tissue culture in combination with more sensitive methods to transduce biological signals, it has become increasingly feasible to detect unknown toxicity or pharmacological effects by using biological systems which are electrically coupled to micro- or nanoelectrodes or field-effect transistors (FETs). The coupling of biomolecules with electronic devices is demonstrated. In order to identify the contributions of the various cell signals we have investigated the coupling of cardiac myocytes with FETs. On the other side such systems can also be used to study the very basics of distributed information processing by interfacing cultured neuronal networks with microelectronic devices.
B. Pichaud, A. Claverie, D. Alquier, H. Richter and M. Kittler
A. Offenhäusser et al., "Interfacing Biology with Electronic Devices", Solid State Phenomena, Vols. 108-109, pp. 789-796, 2005