Papers by Author: Shan Shan Gong

Abstract: An efficient method for the synthesis of 5-formyl-2′-deoxycytidine and its monophosphate has been developed.

Abstract: An improved method for practical synthesis of 4-azaindole from 2-chloro-3-nitropyridine has been developed. In the key step, decarboxylation with acetic acid afforded 3-nitro-2-pyridylacetonitrile in high yield.

Abstract: An AKTI-IV analog with a biotinylated linker extended from the position of the ethyl group in AKTI-IV have been designed and synthesized. Compared to previous alkylation strategy with the iodo biotin linker, the present method alkylated the linker without biotin moiety. The final biotinylation with biotin-OSU afforded the target molecule in much higher overall yield.

Abstract: A novel and stereoselective synthetic method for the preparation of 3α-cholesterylamine was developed. This method had many features, such as easily accessible cholesterol starting material, high stereoselectivity, simple procedure, short reaction time, and good yield.

Abstract: Treatment of protected furanoses with FeCl₃·6H₂O in acetonitrile with microwave irradiation provides an efficient and mild protocol for regioselective removal of anomeric O-acetyl group. This method features cost efficient reagents, simple procedures, and high yields. The experimental results proved that microwave irradiation could notably shorten the reaction time and increase the product yield compared to the conventional thermal heating condition.

Abstract: A novel and efficient method for the preparation of α-D-mannose-1-phosphate has been developed. Phosphitylation of tetraacetylated D-mannose, hydrolysis yielded H-phosphonate monoester. Silylation of H-phosphonate, followed by oxidative coupling and hydrolysis gave protected D-mannose-1-phosphate. Finally, deprotection of tetraacetylated D-mannose-1-phosphate afforded D-mannose-1-phosphate in excellent yield.

Abstract: An improved synthetic method based on glycosyl-1-H-phosphonate diesters has been developed for the preparation of O-d4T-5′-O-glycosyl-1″-phosphoramidate diesters, a kind of potential anti-HIV prodrugs. The target products were synthesized in high yields by using the CCl₄/Et₃N/amino acid methyl ester system.

Abstract: A novel and efficient method for the synthesis of 4-hydroxy-6-substituted-pyrazolo [3,4-d] primidines with acetic acid via phenol esters intermediate has been developed. Compared to the results obtained from the base substituted conditions, acetic acid catalyzed synthesis afforded target products in good yields.

Abstract: A novel and one-pot route for the synthesis of O-glycosyl-5′-H-phosphonate diesters of d4T has been developed. This analogs were synthesized by controlling tandem substitution reaction on PCl₃ with 2,6-lutidine as suitable base.