Abstract: With the advent of the new complex optical system, alignment technology is necessary.
In this paper, is presented an alignment algorithm whose main idea is composed of damped least
square method and singular value decomposition method. In addition, the how and why to enter the
damped factor into algorithm is explained. According to this algorithm, an alignment software
package was compiled and compared self-compiled software with alignment package of CODE V.
Results show that, this self-compiled software is much more valid than alignment package of
CODE V. For a field of view of 2° R-C system, average MTF over the field of view was greater
than 0.3 at 50 line pairs /mm.
Abstract: An efficient phosphorescent white organic light-emitting diode (WOLED) was realized
by using a bright blue-emitting layer, iridium (III) bis [(4, 6-di-fluoropheny)-pyridinato-N, C2’]
picolinate doped 4.4’-bis (9-carbazolyl)-2, 2’-dimethyl-biphenyl, together with tris (2-
Phenylpyridine) iridium and bis (1-phenyl-isoquinoline) acetylacetonate iridium (III) were codoped
into 4,4’-N,N’-dicarbazole-biphenyl layer to provide blue, green, and red emission for color mixing.
The device emission color was controlled by varying dopant concentrations and the thickness of
blue and green-red layers as well as tuning the thickness of exciton-blocking layer. The maximum
luminance and power efficiency of the WOLED were 37100cd/m2 at 17 V and 7.37lm/W at 5V,
respectively. The Commission Internationale de 1’Eclairage (CIE) chromaticity coordinate changes
from (0.41, 0.42) to (0.37, 0.39) when the luminance rangeed from 1000cd/m2 to 30000cd/m2.
Abstract: Microscopy is an important tool in biology and medicine, but it is often limited to optical
imaging structures with high numerical aperture(NA) with a short working distance(wd), for
example NA = 0.6 and wd <1 mm are usual. The common microscope objective is inadequate for
imaging of living cells in culture as an optical imaging structure with both high numerical aperture
and long working distance is required. In this study, a novel optical design has been developed to
meet the long working distance and high resolution power imaging of living cells in a vessel with a
high culture solution thickness, where cells need to be developed in about 48 hours or a week. The
developed optical design was characterized by an ultra-long working distance (wd >13.5 mm) and
high numerical aperture (NA = 0.7). This optical imaging system is not only good for the
subcellular imaging of free-floating cells in culture, but also for the imaging of cells attached at a
surface of vessel.
Abstract: The aim of this work is to assess the cerebrovascular reserve capacity (CVRC) by MR
PWI and photoacoustic brain imaging with “ACZ” tolerance test in mouse and rat, and to compare
their role in evaluating the CVRC. Experimental animals included 2 groups: Wistar-Kyoto rats
(WKY) (12-week-old, 235~265g) were assessed by MRI and BALB/c mice (4-week-old, 25~35g
body weight) were assessed by our photoacoustic imaging system. On photoacoustic imaging, the
diameter of the vascular in the superficial layer of the mouse cortex were measured and compared
between the resting and acetazolamide (Acz)-activated mice, which reflected cerebral blood flow
(CBF) without blood sampling. MR PWI was performed respectively before and after
acetazolamide administrated orally on a clinical 1.5 Tesla GE Signa MR fx/i whole-body MR
system. The region of interest (ROI) was chosen in the bilateral frontal lobe to measure the value of
rCBV, rCBF and MTT. The results show that there was statistical difference between the resting
and acetazolamide (Acz)-activated animals in the values of the diameter of the vascular in the
superficial layer of the mouse cortex by photoacoustic imaging and in the values of rCBV and
rCBF（P＞0.05）of the rat by MRI. It was concluded that the method of PWI and photoacoustic
imaging combined with the “ACZ stress test” can be used to evaluate the CVRC by measuring
values of rCBV and rCBF and diameter of the vascular, respectively.
Abstract: A novel nonlinear confocal microscopic imaging system based on Raman induced Kerr
effect spectroscopy (RIKES) is presented in this paper. The three-dimensional (3-D) microscopic
imaging theory is derived with the Fourier imaging theory and nonlinear optical principle. The
impact of RIKES on the spatial resolution and imaging properties of confocal microscopic imaging
system has been analyzed in detail by the imaging theory. It’s proved that the RIKES nonlinear
microscopic imaging system can effectively improve the imaging contrast and provide more
characteristic information on Raman spectrum and optical nonlinear Kerr effect, thus greatly
improving the imaging quality of confocal microscopic imaging system. It’s shown that the spatial
resolution of RIKES confocal microscopic imaging system is higher than that of two-photon
confocal microscopic imaging system.
Abstract: Highly efficient and unusual structures white organic light-emitting devices were
fabricated based on phosphorescence sensitized 5,6,11,12-tetraphenylnaphthacene. The device
structure was ITO / NPB (30 nm)/CBP: 10% DPVBi (10 nm)/CBP (5 nm) /CBP:x% Ir(ppy)3 : y%
rubrene (20 nm)/ CBP (5 nm)/ CBP: 10% DPVBi (10 nm)/BCP (10 nm)/ Alq3 (30 nm)/LiF(0.5
nm)/Al, where NPB is N,N '-bis- (1-naphthyl)- N,N ' –diphenyl -1, 1 '- biphenyl-4,4 '-diamine as a
hole transporting layer, CBP 4,4,N,N’-dicarbazolebiphenyl as host,DPVBi is 4,4 '-bis(2,2 -diphenyl
vinyl)-1,1 '-biphenyl as blue fluorescent dye，Rubrene is 5,6,11,12,-tetraphenylnaphthacene as
fluorescent dye,Ir(ppy)3 is factris (2-phenylpyridine) iridium as phosphorescent sensitizer .BCP is
2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline as hole-blocking layer, and Alq3 is tris(8-
hydroxyquinoline) aluminum as an electron-transporting layer. In this device, phosphorescent
emissive layer was sandwiched between two blue fluorescent doped ones. This architecture allowed
for resonant energy transfer from both the host singlet and triplet energy levels that minimized
exchange energy losses. Thus, a WOLED with a maximum luminous efficiency of 11.63 cd/A, a
maximum power efficiency of 7.37 lm/W, a maximum luminance of 31770cd/m2, and Commission
Internationale de L’Eclairage coordinates of (0.34.0.36) was achieved.
Abstract: Photoacoustic imaging (also called optoacoustic or thermoacoustic imaging) can image
vascularity clearly with simultaneous high contrast and high spatial resolution, and has the potential
to be an application for tumor diagnosis and treatment monitoring. In a unique photoacoustic
system, a single pulse laser beam was used as the light source for both cancer treatment and for
concurrently generating ultrasound signals for photoacoustic imaging. The photoacoustic system
was used to detect early tumor on the rat back, and the vascular structure around the tumor could be
imaged clearly with optimal contrast. This system was also used to monitoring damage of the
vascular structures before, during and after photodynamic therapy of tumor. This work
demonstrates that photoacoustic imaging can potentially be used to guide photodynamic therapy
and other phototherapies using vascular changes during treatment. Prospective application of
photoacoustic imaging is to characterize and monitor the accumulation of gold nanoshells in vivo to
guide nanoshell-based thermal tumor therapy.
Abstract: Scanning photoacoustic tomography with a piezoelectric double-ring sensor was
explored to image biological tissues, and short laser pulses irradiated tissues to generate acoustic
waves by thermoelastic expansion. The laser-induced photoacoustic waves were detected by a
piezoelectric double-ring sensor. This double-ring sensor has the advantage that it is more sensitive
in the forward direction compared with other conventional sensors. An optical fiber for illumination
of the sample was integrated with the sensor, which enabled reflection-mode detection of ultrasonic
waves. Consequently, two-dimension photoacoustic tomography of biological tissues could be
obtained in a manner analogous to the ultrasound B-scan mode by a linear scan over the tissue
surfaces. To reach a large depth, 1064nm laser light was used in our experiments. The experimental
results showed that the reconstructed photoacoustic images agree well with the structures of the
samples. It demonstrated that this sensor has potential to monitoring tumor angiogenesis, and
antiangiogenic therapy in vivo.
Abstract: Our recent work  theoretically revealed that speckles can be formed when nanofluids
containing a modest volume fraction of nanoparticles are illuminated by a monochromatic laser
beam. This paper focuses on the key issues, including the experimental setup, the particle volume
fraction of the nanofluid, the flow velocity of the nanofluid and the diameter of the pipe, in
measuring the velocities of nanoparticles in nanofluids with laser speckle velocimetry (LSV). First
an experimental setup is established according to the optical characteristics of nanoparticle and the
measuring principles of particle image velocimetry (PIV) and LSV. Then a conclusion is made from
the experimental results that clear speckle patterns can be formed when the particle volume fraction
is between 0.0005% and 0.002% is able to form. Finally, in order to make it applicable to utilize
LSV to measure the velocities of nanoparticles in nanofluids that flow in pipe, nanofluids can not
flow too fast and the diameter of the pipe should not be too small.
Abstract: The scanning laser line source (SLLS) technique is a novel laser-based inspection method
for the ultrasonic detection of small surface-breaking defects. The SLLS approach is based on
monitoring the change in laser generated ultrasound as a laser line source is scanning over a defect.
It has provided enhanced signal-to-noise performance compared to the traditional pitch-catch or
pulse-echo ultrasonic methods. In this paper, an experimental method is presented to detect surface
acoustic waves (SAW) with polyvinylindene fluoride(PVDF) transducer. The ultrasonic signal is
converted into electric signal by piezoelectricity of the PVDF, which is attached to a micro-knife
edge clamped on a metal device. The SAW are excited by employing a pulsed Nd:YAG laser on
aluminum plate with artificial surface-breaking defects. The laser line source is accurately shifted
by the motorized translation stage, while the PVDF is located at a fixed position on the specimen.
When the laser line source is scanning over the defect, the ultrasonic signals are monitored,
meanwhile the characteristic changes in the amplitude and frequency content are observed.
Consequently, the position of the defect can be determined by analyzing the obtained signals. The
experimental system with high sensitivity provides a detection method of small surface-breaking
defects on metal and gives convincing experimental evidence for the interaction mechanism
between the SAW and the surface-breaking defects.